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The Pink Apothecary


It is a genuinely good question. Aren't we just supposed to count by fives and verify medication orders until our eyes bleed? I realize that some of you, med students, PA students, nursing students and even some P1-P2 pharmacy students may not have exposure to pharmacist positions where we are more clinical on the outpatient side. And hey, thats okay! But I'm going to open your eyes a little bit today to what we do in that setting. During my time at Penn Center, a primary care facility in west Philadelphia, I've taken blood pressures every day, multiple times a day. I don't take them for the practice or to double check anyone, I take them because our attendings and residents rely on us to take them. You may think this is a rarity, or something total bizarre, but I'm going to tell you why it works and what exactly we provide for our attendings and residents.

At Penn Center, pharmacists conduct "intervisit" care. Essentially our patients are scheduled to follow up with their primary care doctors every 6 months or so (less or more depending on their problems and stability). However, we all know the work burden of attendings and residents and we all know that sometimes 6 months is too long but you just can't fit people in any earlier. Schedules are backed up, and in most internal med practices this would be where you'd have to default to fitting in phone calls between patients or just trusting your patient to call if there is an emergent issue. At our practice, pharmacists fill that gap. We provide free appointments to our patients during the interim where the patient is waiting for their doctors appointment. So maybe we see them 2 months out, or a few weeks out. Either way, they're not waiting 6 months or more for their next contact with a healthcare provider.

What do we do during these appointments? We handle what we know best: the meds. Our pharmacists have built an extremely tight bond between the attendings and residents at our clinic so they trust us completely when it comes to managing, titrating and adding new medications for chronic diseases. They refer many of their patients to us for teachings, for med management, and sometimes when the patient is so complicated with their regimen that they really just need a second set of eyes. Typically we handle hypertension, and diabetes the most as far as chronic disease states.

For our hypertensive patients we conduct blood pressure tests so that we can properly titrate blood pressure medications. We order labs, we order meds, and we get things done in the interim so our docs can focus on their patient and other non-med related issues during their appointments. I had a patient the other day who popped in for a blood pressure check 3 weeks after seeing his PCP. His blood pressure had been mildly elevated when he last saw his PCP but they had stopped one of his blood pressure medications  because the patient admitted to being non-adherent to all of them. So in order to avoid dropping him too low when he became adherent, we dropped one. 3 weeks later I'm performing an intervisit blood pressure check and I get a blood pressure of 200/100. I panic (inwardly of course) and I go for his other arm to verify. 200/110. After doing a quick symptom evaluation and then leaving (running) to go get my preceptor, we discussed a plan to present to his PCP who happened to be on site. His PCP was extremely grateful he had told him to come in for a BP check with us, agreed with our plan, and we developed a plan to get our patient out of hypertensive urgency.

For our diabetics we do the same: order A1cs and titrate meds to optimize glycemic control as much as possible. We also do insulin and GLP-1 pen teachings so our patients being newly initiated on injectables have the best chance of lowering their A1c by properly administrating the drug to begin with. Our attendings and residents love us for this because there are so many different nuances between pens and they simply don't have time during their appointments to take the 30 minutes to make sure the patient REALLY gets it. We also utilize these appointments for diet and exercise counseling too. Many of our diabetic patients see us for weight management and are extremely grateful we can take the time to talk to them in depth about their lifestyles and what they can do to change that A1c. It takes time, and we have it, so we free up the doc's schedules to see their other high risk patients for issues pharmacy can't handle.

My particular rotation is unique in that my preceptor also handles our refugee patient population and their latent tuberculosis treatment. As you probably know, initiating and finishing LTBI treatment is vital to preventing conversion to active disease and avoiding multi-drug resistant TB development. We initiate, and monitor treatment to ensure that our patients are adherent and safe. In fact, after implementation of the pharmacist-run LTBI clinic, our LTBI treatment completion rate at Penn Center tripled to 94%. That is 11% higher than the goal completion rate set by the CDC!

Now some other questions you might have: why don't the med students handle it? We have 1-2 med students rotating into the clinic. They see their own patients either separate of, or with the residents. They too usually don't have time to dedicate to intervisit care, med teaching and titration between didactic seminars and their own patient load.

What about nurse practitioners? We actually have two great ones! And us doing these intervisit sessions frees them up for drop-in hours! So they handle all of our acute patients who need to be seen right away.

Our medical assistants? They are AMAZING. But hey, we have a ton of patients to see so they have a ton of blood sugar sticks to do, heights/weights to check, prescriptions to organize and rooming to figure out. Plus, when they don't have to do blood pressure they're able to converse with the patient and let us know the chief complaint before we even waltz into the room (and that is a godsend).

This model works. Our attendings and residents are extremely appreciative to have us around and they are constantly recommending their patients to make appointments with us. I've been told numerous times by docs during my six weeks at this center how valued we are as pharmacists. We lessen the burden by just doing what we've been trained to do. Again, this may seem totally weird if your only experience with pharmacists has been through CVS or the basement pharmacy in the hospital, but in ambulatory care this is the norm. Our scope of practice is expanding nationwide at a time where people need help accessing care. In every state we have the ability to immunize. In certain states we have the ability to prescribe medications, which expands public access to care. We are forming collaborative practices with physicians where we prescribe, manage and titrate in states like North Carolina. As students we participate in community outreach events just like other healthcare students do. We are no longer solely tied to our ability to manage product, we are a service based profession. Having us around improves patient safety, medication error rates, and clinical outcomes. As one of the pharmacists at our clinic would say, "we are pharmacists practicing at the top of our license".

So yeah, we carry stethoscopes and they aren't just for show, we're an integral part of the team.


September 15, 2017 No comments


I decided to take a break from doing my antibiotic series of brush letter pharm to do a review of our glucose lowering agents instead. This short review will cover mechanism of action, side effects, weight effects and A1c lowering of our 6 big classes: Biguanide, DPP-4, GLP-1 agonists, Meglitinides, Sulfonylureas and TZDs (side note, it is very difficult to find consistent reporting of A1c lowering of these agents, I did my best to report generally what I've seen in most literature). And before you ask, yes, I left out insulin on purpose. I'll cover that sometime in the future. Enjoy!

Biguanides: Metformin
oral agent

  • A1c lowering: 1-2%
  • MOA: decrease hepatic glucose output, decrease glucose absorption and enhance insulin sensitivity. Work better on fasting blood glucose levels (FBG).
  • Side effects: nausea, diarrhea, cramping, rare/life-threatening lactic acidosis esp. in patients with hepatic or renal impairment
  • Effects on weight: neutral/loss



Sulfonylureas: Glipizide, Glimepiride, Glyburide
oral agent
  • A1c lowering: 0.8-1%
  • MOA: increase insulin secretion from pancreatic beta cells by regulating ATP-sensitive K+ channels. Have effects on both fasting and post-prandial glucose (PPG).
  • Side effects: hypoglycemia, weight gain
  • Effects on weight: gain



Meglitinides: Repaglinide, Nateglinide
oral agent

  • A1c lowering: 0.7-1%
  • MOA: Regulate ATP-sensitive K+ channels on pancreatic beta cells to help improve insulin secretion (same MOA as sulfonylureas, different binding site). Reduces PPG more than FBG.
  • Side effects: hypoglycemia, weight gain
  • Effects on weight: gain



SGLT-2 Inhibitors: Canagliflozin, Empagliflozin, Dapagliflozin
oral agent

  • A1c lowering: 0.8-1%
  • MOA: inhibit SGLT-2 in the proximal tubule of the kidney which prevents reabsorption of glucose and subsequently causes glucose to be excreted from the body through urination
  • Side effects: hypotension, polyuria, yeast infections, UTIs
  • Weight: loss


DPP-4 Inhibitors: Sitagliptin, Saxagliptin, Linagliptin, Alogliptin
oral agent

  • A1c lowering: 0.5%
  • MOA: Inhibits DPP-4, enzyme that breaks down incretin hormone GLP-1. Potentiating action of GLP-1 leads to increased satiety, slowing of gastric emptying (therefore decreased appetite), and increased insulin secretion through glucose-dependent matters. Reduce PPG more so than FBG.
  • Side effects: nausea, otherwise generally well-tolerated
  • Effects on weight: neutral


GLP-1 receptor agonists: Exenatide, Liraglutide, Lixisenatide, Dulaglutide
injectable agent

  • A1c lowering: 0.8-1%
  • MOA: Potentiate the action of incretin hormone GLP-1 which leads to increased satiety, slowing of gastric emptying (therefore decreased appetite), and increased insulin secretion through glucose-dependent matters. Reduces PPG more than FBG.
  • Side effects: nausea, diarrhea, cramping
  • Effects on weight: loss



TZDs: pioglitazone, rosiglitazone
oral agent
  • A1c lowering:1-1.25%
  • MOA: inhibits PPAR-y which encourages storage of fatty acids and utilization of glucose. Enhances insulin sensitivity. Works on both FBG and PPG levels.
  • Side effects: fluid retention (can lead to acute decompensated HF), fractures
  • Effects on weight: gain



September 03, 2017 No comments



Hello pharmacy friends! As I go through my APPE year, I'm growing my arsenal of easy-to-access and usable resources. One great way I've found to do this is to create pocket cards! Pocket cards are small info sheets able to be printed out and kept in your white coat pocket! For each rotation I've been on I create a few for the disease states I see most frequently. I've had some friends ask if I could share them, so I am going to compile them all here in one post, organized by subject!

Disclaimer: these are by NO means an exhaustive resource. Each card was created using the most up-to-date guidelines I could find, and as always guidelines are subject to change and are not applicable to each and every patient. These are just meant to serve as a basic resource. All of these were created by myself, so if you'd like to share feel free but please credit my blog if you plan on advertising them somewhere!


Infectious Disease

Abx Spectrums


Tuberculosis 





Community-Acquired Pneumonia




Diabetes and Endocrinology

Estimated Plasma Glucose per A1c levels
This calculator from the ADA is also a great resource for calculating this on the fly: https://professional.diabetes.org/diapro/glucose_calc

September 02, 2017 No comments
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About Me


|Gianna|
Previously titled "The Philly Pharm Student", The Pink Apothecary is a documentation of my adventures in pharmacy. From graduating pharmacy school with my PharmD to starting residency away from my home of Philadelphia, I hope to share tips, advice and commentary on how I've made it through and fell in love with my career.



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