ADA 2018: Highlight Reel
This fall/winter have been a busy season for guideline updates! From the buzz surrounding the ACC/AHA '17 hypertension guidelines to these new guidelines from the American Diabetes Association, it is clear that there are some changes on the horizon. I just finished reading through the 2018 ADA guidelines and figured I'd put together a summarized student break-down about some notable recommendations/sections that I found interesting. I'm also going to include some of my own tables that I've created to help me remember testing criteria and risk factors, feel free to download and use them as well!
Improving Care and Promoting Health in Populations
The ADA recommendations regarding diabetes and population health are focused around the importance of patient-centered care. Care should be aligned with evidence-based guidelines, and balanced with patient preference, prognoses and comorbidities. In other words, the focus of care should really be centered around the individual and not the disease.
Something I found interesting about this section was that the national mean A1c has declined from 7.6% (1999-2002) to 7.2% (2007-2010), but despite this up to 50% of patients with diabetes do not meet their targets for glycemic control, lipids or blood pressure. Only 14% meet the recommendations for all three. This has huge implications considering the risk for cardiovascular disease associated with diabetes and the recent push to prescribe anti-diabetic agents with additional cardiovascular benefit.
In order to improve upon our current diabetes care delivery standards and quality of care delivered, the ADA introduces the Chronic Care Model (CCM). It consists of six elements:
- Delivery system design (moving from a reactive to a proactive care delivery system where planned visits are coordinated through a team-based approach)
- Self-management support
- Decision support (basing care on evidence-based, effective care guidelines)
- Clinical information systems (using registries that can provide patient-specific and population-based support to the care team)
- Community resources and policies (identifying or developing resources to support healthy lifestyles)
- Health systems (to create a quality-oriented culture)
To sum up: "Redefining the roles of the health care
delivery team and empowering patient
self-management are fundamental to
the successful implementation of the
CCM. Collaborative, multidisciplinary
teams are best suited to provide care
for people with chronic conditions such
as diabetes and to facilitate patients’
self-management."
Included in the very long list of potential recommendations to improve the system are: empowering and educating patients, the incorporation of telemedicine in rural communities, addressing psychosocial issues, and reducing out of pocket costs for diabetes medications and eye/dental appointments. One of the most important points is to remember that the patient IS a part of the care team, and we cannot hope to achieve control of this disease without their voice.
Although there are plenty of recommendations on how to improve our system of delivery, we must also address the obstacles patients face in their healthcare journey. The ADA reports that 23% of the cases of uncontrolled A1c, lipids, and blood pressure can be attributed to poor medication-taking behaviors. These behaviors can include patient factors like the fear of taking medicine, or forgetfulness, and medication factors like complexity or cost. If a patient's adherence is below 80% then intensification of therapy should not be considered until the adherence issues are addressed. As a pharmacy student who has rotated in primary care settings, the fact that only 23% of cases can be attributed to poor adherence surprised me. However, I believe this highlights the complexity of care associated with diabetes and that medication adherence is not always the core problem. Many times as practitioners, we assume that it is. This also stresses the importance of looking at the patient as an individual who is likely struggling with diabetes in the context of multiple dimensions: medically, politically, socially and emotionally. Social determinants, such as food insecurity, language barriers, community support, and homelessness are often huge obstacles that prevent patients from getting proper diabetes care and should be considered when formulating a treatment plan.
The Classification and Diagnosis of Diabetes
To help summarize this section i've devised some tables that include when to test, how often to follow up on testing, some risk information and the diagnosis criteria
Prediabetes
** A1c is preferred due to its strong predictive ability of subsequent diabetes development
Type 2 Diabetes Mellitus
Comprehensive Medical Evaluation and Comorbidities
This section stresses the importance of comprehensive medical care, where all comorbidities, psychosocial issues and patient factors are evaluated and addressed initially and at future follow-up visits. Additionally, aspects like past medical and family history, social history, medications, vaccinations, physical exam, laboratory measures and technology use should be documented initially and at each visit.
This a great section to read to understand many of the comorbidities patients with diabetes are at risk for or commonly develop and how to manage them. In particular, I'd like to highlight the recommendations for immunizations. Patients with diabetes are especially at risk to developing infections like pneumococcal pneumonia and influenza, which could led to further complications like hyperglycemia due to infection, bacteremia, and even death. It is important that vaccinations are talked about and documented at every follow up visit and that precise records are kept.
Immunizations recommendations
- Annual influenza is recommended to anyone >6 months of age including those with diabetes
- 3-dose series of Hepatitis B should be administered to patients 19yo-59yo with diabetes. Vaccination can be considered to patients with diabetes >60yo
- Pneumococcal pneumonia vaccination should include the 4-dose PCV13 before age 2yo, and then an additional PPSV23 for ages 2-64yo.
- Zoster, HPV and TdAP vaccines are recommended following the same CDC guidelines for the general public without diabetes
Understanding the recommendations for pneumococcal pneumonia can be pretty complicated when presented with a patient >65yo, so here is a flow chart to explain:
Glycemic Targets
There is little evidence directed us on how to prescribe self-monitoring blood glucose for patients on basal insulin and oral agents compared to those on intensive insulin regimens. That being said, the decision to prescribe self-monitoring blood glucose should take into account the patient's preference, ability and glycemic control. For patients on intensive insulin regimens, the ADA lists many situations where testing may be recommended (before meals, after meals, before driving, at bedtime, the list goes ON). The burden of testing this many times a day (6-10 if you went by their recommendations) makes it even more necessary to include patient factors in the decision on how many times to test. Otherwise, the goals themselves haven't really changed:
A1c goals
- Non-pregnant adults: <7%
- More stringent goals like <6.5% can be recommended for selected individuals if it can be achieved without hypoglycemia or other adverse effects or polypharmacy
- Less stringent goals like <8% can be considered for those with a history of severe hypoglycemia, limited life expectancy, advanced micro or macrovascular complications or extensive comorbidities
Blood glucose goals
- FPG 80-130
- PPG <180
Pharmacologic Approaches
My most FAVORITE section of course! The ADA really out did themselves on this section when it comes to pretty charts and tables to break down the medication classes available, cost, max doses, renal/hepatic impairment considerations and more. I HIGHLY recommend checking out this section for yourself. Below is their treatment algorithm AKA my new best friend:
Of interest are the new recommendations for agents that confer additional cardiovascular benefits (grey box). The guidelines now recommend that for patients with an A1c of 9%-10 and ASCVD, that liraglutide or empagliflozin be added as an additional agent to metformin and lifestyle modifications. This is based off results from the landmark trials EMPA-REG OUTCOMES and LEADER where these agents showed a decrease in cardiovascular events and cardiovascular death. In 2008 the FDA issued a guidance that all new diabetic medications be evaluated on their cardiovascular outcomes impact, so we are now seeing the inclusion of agents with cardiovascular benefit being added to the guidelines for those with ASCVD. Currently three diabetic agents hold FDA-approved indications for to prevent cardiovascular events: liraglutide, canagliflozin and empagliflozin. However, canagliflozin did not have a significant reduction in cardiovascular death in a combined analysis of the CANVAS and CANVAS-R trials and therefore it cannot be recommended as an agent to prevent CV death.
For more information about medications used in diabetes, check out my Brush Letter Pharm post featuring glucose lowering agents.
Conclusion
I hope you enjoyed these highlights! I really recommend reading through the entire guideline if you'll be on a primary care rotation. It also includes guidance on the treatment of older adults, children/adolescents, lifestyle management and further information on cardiovascular disease management. I wish I could go through it all but its time for me to get back to residency apps!
Reference:
1. American Diabetes Association. Standards of Medical Care in Diabetes 2018. Diabetes Care. 2018; 41(1). http://care.diabetesjournals.org/content/diacare/suppl/2017/12/08/41.Supplement_1.DC1/DC_41_S1_Combined.pdf
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